Table 1.
Major Proteins Identified in Neat Serum or after Normalization
| Protein name | Peptide number (ratio to total peptide number) | ||
|---|---|---|---|
| Neat serum | MARS-14 | PM | |
| Albumina | 3513 ± 327 (37.40%) | 86 ± 36 (1.48%) | 296 ± 33 (3.69%) |
| Iga | 1790 ± 214 (19.06%) | 3 ± 2 (0.05%) | 619 ± 87 (7.71%) |
| Antitrypsina | 5 ± 1 (0.05%) | 0 | 5 ± 2 (0.06%) |
| Transferrina | 364 ± 116 (3.88%) | 0 | 15 ± 4 (0.19%) |
| Haptoglobina | 105 ± 26 (1.12%) | 0 | 22 ± 3 (2.74%) |
| Fibrinogena | 4 ± 2 (0.04%) | 1 ± 1 (0.02%) | 16 ± 3 (0.20%) |
| Alpha-2-macroglobulina | 318 ± 37 (3.39%) | 7 ± 3 (0.12%) | 61 ± 8 (0.76%) |
| Alpha-1-acid glycoproteina | 45 ± 7 (0.48%) | 0 | 2 ± 2 (0.02%) |
| Apolipoprotein AIa | 142 ± 9 (1.51%) | 129 ± 15 (2.22%) | 222 ± 50 (2.77%) |
| Apolipoprotein AIIa | 46 ± 8 (0.49%) | 50 ± 10 (0.86%) | 37 ± 8 (0.46%) |
| A Chain A, Human Complement Component C3a | 159 ± 18 (1.69%) | 2 ± 1 (0.03%) | 630 ± 162 (7.85%) |
| B Chain B, Human Complement Component C3a | 108 ± 14 (1.15%) | 24 ± 4 (0.41%) | 374 ± 46 (4.66%) |
| Transthyretina | 14 ± 3 (0.15%) | 0 | 65 ± 15 (0.81%) |
| Vitamin D-binding protein | 85 ± 6 (0.91%) | 327 ± 22 (5.62%) | 30 ± 3 (0.37%) |
| Ceruloplasmin precursor | 70 ± 3 (0.75%) | 482 ± 75 (8.29%) | 162 ± 28 (2.02%) |
| Complement C4-A precursor | 108 ± 13 (1.15%) | 229 ± 23 (3.94%) | 653 ± 134 (8.14%) |
| Hemopexin | 50 ± 15 0.53%) | 624 ± 49 (10.74%) | 5 ± 2 (0.06%) |
| Apolipoprotein B-100 precursor | 154 ± 17 (1.64%) | 306 ± 22 (5.26%) | 204 ± 66 (2.54%) |
| C4 binding protein, α chain precursor | 41 ± 2 (0.44%) | 57 ± 7 (0.98%) | 158 ± 18 (1.97%) |
| Fibronectin precursor | 45 ± 6 (0.48%) | 101 ± 16 (1.74%) | 312 ± 40 (3.87%) |
a
Top 14 serum proteins that the MARS-14 kit is designed to deplete.