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Gene GC-content distribution in three representative placental species. (A) Third-codon position GC content (GC3); (B) 5′- and 3′-flanking GC content. (Curved line) Estimated GC distribution of the common placental ancestor. (Gray histogram) Observed distributions of extant species. As compared to the estimated ancestral state, humans show a conservative pattern, tenrecs (Echinops telfairi) a global enrichment in GC, and mice (Mus musculus) a decreased variance in GC across genes.
