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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Nat Chem. 2010 May 23;2(8):638–643. doi: 10.1038/nchem.665

Figure 2. A route to stereodefined skipped polyenes by titanium-mediated reductive cross-coupling of vinylcyclopropanes with alkynes.

Figure 2

Inline graphic = Stereochemical relationships established in this skipped polyene synthesis; Inline graphic = stereochemistry set in a stereospecific fashion (E or Z); Inline graphic = stereochemistry retained from cyclopropane; Inline graphic and Inline graphic = stereochemistry set in a stereoselective fashion (≥20:1); Inline graphic = stereochemistry is set as a function of the reaction mechanism. Inline graphic = carbon–carbon bond formed in Ti-mediated cross-coupling.