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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Neurochem. 2010 Apr 6;114(1):13–27. doi: 10.1111/j.1471-4159.2010.06736.x

Figure 2.

Figure 2

Overall structure of the TLR4/MD-2 complex. (A) Side and top view of an m-shaped receptor multimer composed of two copies of the TLR4/MD-2 complex arranged symmetrically. (B) Close-up view of the LPS binding site on the TLR4/MD-2 interface. LPS interacts with a large hydrophobic pocket in MD-2 and directly bridges the two components of the multimer. The primary interface between TLR4 and MD-2 is formed before binding LPS, and the dimerization interface is induced upon LPS binding. (C) Molecular structure of LPS.