Table 1.
Baseline characteristics by body weight among t-PA-treated patients
| Variables | Body weight >100 kg (n = 20) | Bodyweight ≤100kg (n = 292) | p value |
|---|---|---|---|
| Age, years | 56.9 ± 10.6 | 68.7 ± 11.0 | <0.001 |
| Female | 6 (30) | 128 (44) | 0.253 |
| Race | 0.452 | ||
| White, non-Hispanic | 12 (60) | 193 (66) | |
| Black | 8 (40) | 72 (25) | |
| Others | 0 (0) | 27 (9) | |
| Baseline NIHSS score (median and range) | 14 (1–37) | 10 (3–28) | 0.156 |
| Rate of symptomatic ICH | 3 (15) | 17 (6) | 0.129 |
| Comorbid conditions | |||
| Atrial fibrillation | 0 (0) | 58 (20) | 0.018 |
| Diabetes mellitus | 7 (35) | 61 (21) | 0.163 |
| Hypertension | 16 (80) | 189 (66) | 0.227 |
| Hyperlipidemia | 7 (44) | 70 (29) | 0.256 |
| Congestive heart failure | 1 (5) | 43 (15) | 0.327 |
| Myocardial infarction | 7 (38) | 63 (23) | 0.168 |
| Hepatic disease | 0 (0) | 9 (3) | 1.0 |
| Atherosclerosis | 7 (41) | 82 (33) | 0.597 |
| Current smoking | 10 (50) | 94 (33) | 0.144 |
| Alcohol use | 13 (65) | 137 (49) | 0.173 |
| Prior stroke | 0 (0) | 45 (15) | 0.091 |
| Prior TIA | 3 (15) | 47 (17) | 1.0 |
| Heparin use prior to baseline stroke | 0 (0) | 5 (2) | 1.0 |
| Aspirin use prior to randomization | 8 (40) | 119 (41) | 1.0 |
| Admission serum glucose, mg/dl | 149 ± 74 | 148 ± 70 | 0.965 |
| Admission systolic BP, mm Hg | 153 ± 22 | 159 ± 19 | 0.255 |
| Admission diastolic BP, mm Hg | 88 ± 11 | 84 ± 13 | 0.209 |
| Presence of hypodensity on CT | 2 (11) | 24 (8) | 0.656 |
| Time from onset to treatment, min | 116 ± 37 | 119 ± 37 | 0.702 |
| Left hemisphere location | 13 (65) | 122 (42) | 0.210 |
| Classification of the stroke subtype | 0.671 | ||
| Small-vessel occlusive | 4 (22) | 27 (9) | |
| Cardioembolic | 5 (28) | 117 (40) | |
| Large-vessel occlusive | 3 (17) | 56 (19) |
Figures in parentheses are percentages, unless otherwise indicated.
TIA = Transient ischémie attack; BP = blood pressure.