Table 2.
Univariate predictors of clinical outcomes at 3 months
| Variables | t-PA treated patients (n = 312) |
Placebo (n = 312) |
||||
|---|---|---|---|---|---|---|
| favorable outcome (n= 168) | worse outcome (n = 144) | p value | favorable outcome (n= 127) | worse outcome (n = 185) | p value | |
| Age, years | 65 ± 12 | 71 ± 10 | <0.001 | 63 ± 13 | 68 ± 11 | <0.001 |
| Female | 67 (40) | 67 (47) | 0.253 | 46 (36) | 82 (44) | 0.162 |
| Race | 0.030 | 0.831 | ||||
| White, non-Hispanic | 121 (72) | 84 (58) | 80 (63) | 118 (64) | ||
| Black | 37 (22) | 43 (30) | 36 (28) | 53 (29) | ||
| Others | 10 (6) | 17 (12) | 11 (9) | 14 (8) | ||
| Baseline NIHSS score (median and range) | 10 (1–31) | 18 (3–37) | <0.001 | 10 (1–28) | 18 (4–33) | <0.001 |
| Hyperlipidemia | 41 (28) | 36 (32) | 0.495 | 30 (29) | 34 (23) | 0.304 |
| Hypertension | 95 (57) | 110 (79) | <0.001 | 77 (61) | 126 (69) | 0.180 |
| Diabetes mellitus | 24 (14) | 44 (31) | 0.001 | 24 (19) | 39 (21) | 0.668 |
| Congestive heart failure | 15 (9) | 29 (21) | 0.005 | 21 (17) | 34 (19) | 0.651 |
| Atrial fibrillation | 25 (15) | 33 (23) | 0.081 | 16 (13) | 41 (22) | 0.037 |
| Myocardial infarction | 40 (25) | 30 (22) | 0.586 | 28 (23) | 33 (19) | 0.466 |
| Hepatic disease | 4 (2) | 5 (4) | 0.736 | 3 (2) | 6 (3) | 0.744 |
| Atherosclerosis | 44 (29) | 45 (4) | 0.065 | 31 (28) | 50 (31) | 0.686 |
| Current smoking | 61 (37) | 43 (31) | 0.276 | 53 (42) | 58 (32) | 0.072 |
| Alcohol use | 89 (54) | 61 (45) | 0.133 | 68 (55) | 76 (42) | 0.026 |
| Prior stroke | 22 (13) | 23 (16) | 0.519 | 18 (15) | 20 (11) | 0.38 |
| Prior transient ischémie attack | 29 (18) | 21 (16) | 0.757 | 23 (19) | 26 (15) | 0.426 |
| Heparin use prior to baseline stroke | 1 (1) | 4 (3) | 0.184 | 2 (2) | 4 (2) | 1.000 |
| Aspirin use prior to randomization | 65 (39) | 62 (43) | 0.488 | 36 (28) | 53 (29) | 1.000 |
| Admission serum glucose, mg/dl | 142 ± 70 | 157 ± 71 | 0.064 | 145 ± 67 | 155 ± 85 | 0.261 |
| Admission systolic BP, mm Hg | 153 ± 23 | 155 ± 21 | 0.535 | 157 ± 27 | 159 ± 28 | 0.478 |
| Admission diastolic BP, mm Hg | 85 ± 14 | 85 ± 13 | 0.686 | 89 ± 18 | 89 ± 15 | 0.781 |
| Presence of hypodensity on initial CT | 8 (5) | 18 (13) | 0.022 | 15 (12) | 13 (7) | 0.165 |
| Time from onset to treatment, min | 118 ± 37 | 121 ± 38 | 0.537 | 123 ± 38 | 118 ± 35 | 0.271 |
| Left hemisphere location | 83 (49) | 77 (53) | 0.896 | 69 (54) | 82 (44) | 0.131 |
| Classification of the stroke subtype | 0.002 | 0.071 | ||||
| Small-vessel occlusive stroke | 25 (15) | 6 (4) | 20 (16) | 10 (5) | ||
| Cardioembolic stroke | 53 (32) | 69 (49) | 46 (37) | 73 (40) | ||
| Large-vessel occlusive stroke | 28 (17) | 31 (22) | 21 (17) | 45 (25) | ||
| Body weight > 100 kg | 10 (6) | 10 (7) | 0.818 | 12 (9) | 20 (11) | 0.850 |
Figures in parentheses are percentages, unless otherwise indicated. BP = Blood pressure.