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View full-text article in PMC

. 2010 Jun 30;2010:321950. doi: 10.1155/2010/321950

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Copyright © 2010 Ralf Müller et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Association of clinical relapses of rituximab (Rtx)-treated pemphigus vulgaris (PV) patients and the reappearance of IgG against distinct regions of the Dsg3 ectodomain. Three of the 6 PV patients (PV3, PV6, PV23) showed an increase of IgG reactive with the Dsg3EC1 subdomain upon clinical relapse after Rtx therapy. Patient PV13 showed increased serum levels of IgG against the Dsg3EC4 subdomain while patients PV5 and PV19 did not show altered IgG levels against any of the studied Dsg3 subdomains upon clinical relapse.