Table 2.

Data for all subjects developing diabetes: women at baseline, and men and women at follow-up.

	Women (n=60)					Men (n=107)
	Baseline		Follow-upa			Follow-upa
Variables	Mean (95% CI)	P valueb	Mean (95% CI)	P valueb	P valuec	Mean (95% CI)	P valueb	P valued
Age (years)	49.3 (48.1–50.4)	0.934	57.4 (56.3–58.6)	0.984	<0.001	57.9 (57.0–58.8)	1.000	0.487
Height (m)	1.65 (1.64–1.67)	0.401	1.65 (1.63–1.66)	0.560	<0.001	1.78 (1.77–1.79)	0.207	<0.001
Weight (kg)	81.2 (76.7–85.7)	<0.001	86.1 (807–91.6)	<0.001	<0.001	93.5 (90.4–96.6)	<0.001	0.021
BMI (kg/m2)	29.7 (28.1–31.2)	<0.001	31.7 (29.7–33.7)	<0.001	<0.001	29.5 (28.6–30.2)	<0.001	0.040
Waist (cm)	92 (88–95)	<0.001	99 (95–103)	<0.001	<0.001	102 (100–104)	<0.001	0.115
Hip (cm)	107 (104–110)	<0.001	110 (106–114)	<0.001	0.020	106 (104–107)	0.002	0.070
Waist/hip	0.86 (0.84–0.87)	<0.001	0.90 (0.88–0.91)	<0.001	<0.001	0.97 (0.95–0.98)	<0.001	<0.001
Wa2HtRe	4.97 (4.62–5.35)	<0.001	5.76 (5.30–6.25)	<0.001	<0.001	5.81 (5.58–6.04)	<0.001	0.808
IGF1 (μg/l)e	169 (156–183)	0.058	152 (139–167)	0.023	0.006	149 (139–159)	0.163	0.702
Systolic BP (mmHg)	128 (124–131)	0.017	143 (138–148)	0.003	<0.001	146 (142–149)	<0.001	0.330
Diastolic BP (mmHg)	79 (77–81)	0.004	84 (82–87)	0.050	<0.001	89 (87–91)	<0.001	0.012
Glucose (mmol/l)
0 h	5.2 (5.1–5.3)	<0.001	6.8 (6.4–7.2)	<0.001	<0.001	7.7 (7.2–8.1)	<0.001	0.007
2 hf	5.8 (5.5–6.1)	<0.001	12.3 (11.5–13.2)	<0.001	<0.001	13.4 (12.6–14.3)	<0.001	0.066
Insulin (pmol/l)e
0 h	89 (80–100)	<0.001	144 (125–166)	<0.001	<0.001	138 (125–153)	<0.001	0.637
2 hf	354 (302–416)	<0.001	632 (512–781)	<0.001	<0.001	451 (394–516)	<0.001	0.006
IGFBP1 (μg/l)e
0 h	25 (21–29)	<0.001	30 (26–35)	0.011	0.007	18 (16–21)	0.835	<0.001
2 hf	14 (13–16)	<0.001	14 (12–17)	0.002	0.463	8 (7–10)	0.149	<0.001
2 h/0 h (%)f	57 (53–61)	0.001	48 (43–54)	0.346	0.011	47 (42–52)	0.103	0.794
Obesity frequencyg	44%		55%			38%
FHD frequency	80%		83%			79%
Still menstruatingh	56%		12%

^aFollow-up 8 years for women and 10 years for men.

^bUnpaired t-test, compared to matched controls.

^cPaired t-test, compared to baseline.

^dUnpaired t-test, men versus women.

^eGeometric mean.

^f2-h Follow-up values: n=37 in women and n=67 in men.

^gAccording to WHO criteria (BMI≥30).

^hSelf-reported regular or irregular bleeding.