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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Cell. 2010 May 28;141(5):859–871. doi: 10.1016/j.cell.2010.03.053

Figure 3.

Figure 3

LTD is abolished in hippocampal slices from caspase-3 knockout (−/−) mice. (A) Input-output relationship in caspase-3 −/− and wildtype mice (2–4 weeks age). fEPSP slope was plotted against amplitude of presynaptic volley at four different stimulus intensities (10 µA, 20 µA, 50 µA and 100 µA). Graph indicates mean ± SEM (p>0.05, n=16). (B) Low frequency stimulation (LFS, 1 Hz, 15 min) failed to induce LTD in caspase-3 −/− slices (p<0.01, n=6). (C) Magnitude of LTP induced by tetanic stimulation (Tet) was not different between caspase-3 −/− and wildtype slices (p>0.05, n=6). See also Figure S2.