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. Author manuscript; available in PMC: 2010 Jul 26.
Published in final edited form as: Nature. 2005 Aug 18;436(7053):1030–1034. doi: 10.1038/nature03894

Figure 1. Spermatogonial depletion and Sertoli-cell-only syndrome in ERM−/− mice.

Figure 1

a, Ten-week wild-type (left) and ERM−/− (right) testes. b, Wild-type seminiferous tubules. c–e, Progressive germ-cell loss in ERM−/− testis at 4 weeks (c), 6 weeks (d) and 10 weeks (e). f, Persistent Sertoli cells in ERM−/− tubules indicated by GATA-1 expression at 10 weeks. g–k, Normal spermatogenesis with spermatogonial depletion. Histology of wild-type (g) or ERM−/− (h–k) testes at 6 weeks of age. Diagrams of seminiferous epithelium are shown at the bottom: ES, elongated spermatid; RS, round spermatid; PS, pachytene spermatocyte; PL, preleptotene spermatocyte; Sg, spermatogonium; Sertoli, Sertoli cell; asterisks, missing cell populations.