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. Author manuscript; available in PMC: 2011 Jun 25.
Published in final edited form as: Circ Res. 2010 Apr 29;106(12):1807–1817. doi: 10.1161/CIRCRESAHA.109.212969

Figure 5. FXR activation ameliorates vascular calcification in ApoE−/− mice with CKD without affecting the development of atherosclerosis.

Figure 5

A) En face analysis of atherosclerosis in 5/6 nephrectomized ApoE−/− mice treated with INT-747. Mice were fed western diet supplemented with INT-747 for 12 weeks. B) Aortic calcium content in 5/6 nephrectomized ApoE−/− mice treated with INT-747. C) Calcified area stained by Von Kossa in aortic sinus of 5/6 nephrectomized ApoE−/− mice treated with vehicle (left) or 10 mg/kg INT-747 (right). D) Quantification of calcified lesion area in the aortic sinus. The arrow indicates calcified lesion.