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. Author manuscript; available in PMC: 2010 Jul 26.

Published in final edited form as: Dev Dyn. 2008 Sep;237(9):2450–2459. doi: 10.1002/dvdy.21678

Panel A is representative photomicrographs of renal cortex from P25 bcl-2 +/+, Hox b7/bcl-2;bcl-2 +/+, bcl-2 −/− and Hox b7/bcl-2;bcl-2 −/− mice were hematoxylin and eosin stained. Please note glomerular hypertrophy in bcl-2 −/− mice. In Panel B, glomeruli/midsigittal section, glomerular volume and cell numbers/glomeruli were determined (N> 30 mice). Please note that Hoxb7 driven expression of bcl-2 significantly increased total glomerular numbers (bcl-2 +/+ 15,204 ±1,492 vs Hox b7/bcl-2;bcl-2 +/+ 34,750±3,512;P<0.03 and bcl-2 −/− 4,047± 278 vs Hox b7/bcl-2;bcl-2 −/− 11,828±951;P<0.03; n=5). In Panel C, mid-sagittal kidney sections from P 25 bcl-2 +/+ and Hox b7/bcl-2;bcl-2 +/+ mice were stained with Lotus tetragonobolus agglutinin to identify proximal tubules.

Panel A is representative photomicrographs of renal cortex from P25 bcl-2 +/+, Hox b7/bcl-2;bcl-2 +/+, bcl-2 −/− and Hox b7/bcl-2;bcl-2 −/− mice were hematoxylin and eosin stained. Please note glomerular hypertrophy in bcl-2 −/− mice. In Panel B, glomeruli/midsigittal section, glomerular volume and cell numbers/glomeruli were determined (N> 30 mice). Please note that Hoxb7 driven expression of bcl-2 significantly increased total glomerular numbers (bcl-2 +/+ 15,204 ±1,492 vs Hox b7/bcl-2;bcl-2 +/+ 34,750±3,512;P<0.03 and bcl-2 −/− 4,047± 278 vs Hox b7/bcl-2;bcl-2 −/− 11,828±951;P<0.03; n=5). In Panel C, mid-sagittal kidney sections from P 25 bcl-2 +/+ and Hox b7/bcl-2;bcl-2 +/+ mice were stained with Lotus tetragonobolus agglutinin to identify proximal tubules.