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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Int J Clin Rheumtol. 2010 Apr;5(2):199–214. doi: 10.2217/ijr.10.3

Figure 2. Cellular and extracellular matrix changes associated with age that lead to chondrocyte death and osteoarthritis development in articular cartilage.

Figure 2

Summary of cell-based (intrinsic and extrinsic) factors known to change with age and alter cell viability (see text for details).

ECM: Extracellular matrix; MMP: Matrix metalloproteinase; RAGE: Receptor for advanced glycation end products; ROS: Reactive oxygen species.