Table 2.
Steady-state pharmacokinetic parameters for vildagliptin 100 mg following morning or evening dosing
| Parameter | Morning dosing (n = 36) | Evening dosing (n = 36) |
|---|---|---|
| Cmax (ng ml−1) | 684 ± 187 | 578 ± 152 |
| AUC(0,7 h) (ng ml−1 h) | 2062 ± 438 | 1977 ± 527 |
| AUC(0,∞) (ng ml−1 h) | 2414 ± 561 | 2427 ± 692 |
| tmax (h) | 1.00 (0.50–2.00) | 1.00 (1.00–3.00) |
| t1/2 (h) | 3.43 ± 1.58 | 2.45 ± 0.53 |
Data are mean ± SD except for tmax values, which are median (range). Cmax, maximum plasma concentration; AUC(0,7 h), area under the plasma concentration–time curve from time 0 to 7 h; AUC(0,∞), area under the plasma concentration–time curve from time 0 extrapolated to infinity; tmax, time to reach Cmax; t1/2, terminal elimination half-life.