Table 3.

Treatment with corticosteroids and combination therapy – results of dividing the cohort by different years

Year	% treated before	% treated after	Difference %	Adjusted OR	95% CI	P value
1997
CS	19.9%	19.9%	0.0%	0.89	0.60, 1.30	0.542
CT	5.6%	14.3%	8.7%	2.83	0.76, 10.59	0.122
1998
CS	20.7%	19.4%	−1.3%	0.82	0.57, 1.18	0.293
CT	6.0%	15.0%	9.0%	3.09	0.93, 10.30	0.066
1999
CS	22.4%	18.1%	−4.3%	0.66	0.47, 0.93	0.019
CT	5.9%	16.7%	10.8%	3.18	1.02, 9.95	0.047
2000†
CS	22.2%	17.7%	−4.5%	0.65	0.46, 0.92	0.014
CT	5.1%	19.3%	14.2%	4.71	1.56, 14.21	0.006
2001
CS	21.3%	18.1%	−3.2%	0.70	0.49, 0.99	0.042
CT	8.1%	17.1%	9.0%	2.22	0.84, 5.86	0.108
2002
CS	21.4%	17.3%	−4.1%	0.65	0.45, 0.94	0.023
CT	8.7%	18.3%	9.6%	1.94	0.73, 5.16	0.182
2003
CS	20.9%	17.3%	−3.6%	0.66	0.44, 0.97	0.036
CT	9.9%	17.4%	7.5%	1.65	0.59, 4.59	0.338

CS, all corticosteroid therapy; CT, corticosteroid users also receiving a cytotoxic agent.

^†A priori comparison before and after publication of guidelines.