Figure 3.

Oral administration of CHZ improves motor performance in tg/tg mice. A, The performance of tg/tg (n = 10; orange symbols) and +/+ (n = 11; black symbols) mice was evaluated daily using an accelerating rotarod paradigm. CHZ treatment is denoted with the vertical bar. CHZ improved the motor performance of tg/tg but not wild-type (wt) mice. B, Maximum speed achieved before CHZ treatment (average of 5 d), during treatment (CHZ, average of 2 weeks), and after terminating treatment (Post, average of the last 5 d) for +/+ and tg/tg mice. ***p < 0.001 (one-way ANOVA, followed by Bonferroni's correction). n.s., Not significant.