Skip to main content
. Author manuscript; available in PMC: 2010 Jul 26.
Published in final edited form as: Ann Neurol. 2005 Jan;57(1):152–155. doi: 10.1002/ana.20358

Fig 2.

Fig 2

The resistance to experimental febrile seizures (FSs) in IL-1R1−/− mice appears independent of potential confounders related to their genetic background. (A) Experimental FS threshold in (wild-type) C57BL mice is less than in (wild-type) 129/Sv mice (39.7 ± 0.2°C vs 41.3 ± 0.2°C). A difference of gene repertoires between these two strains could underlie changes in susceptibility to the induction of experimental FSs. However, the absence of interleukin-1 type 1 receptor (IL-1R1) leads to significant increase of seizure threshold in both genetic strains. The asterisk indicates different from threshold of wild-type 129/Sv and C57BL. Minus sign indicates different from C57BL. (B) Infusion of 5ng IL-1β, but not of vehicle (water) into the cerebral ventricles (icv), does not affect seizure threshold of the IL-1R1−/− mice, but significantly (asterisk) decreases seizure threshold of wild-type mice of a similar genetic background, suggesting that the resistance to experimental FSs found in IL-1R1−/− mice is specific to the null mutation in the receptor gene.