Table 3.
Presence and severity of the nonvisual symptoms in the worse eye
| Nonvisual symptoms (GSS-SYMP-6)* |
Baseline (N = 132)a |
Week 4 (N = 127)b,c |
Week 4 vs BaselineP-value |
Week 8 (N = 125)d,e |
Week 8 vs BaselineP-value | |||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | |||
| Burning, smarting, stinging | ||||||||
| Absence of symptom | 95 | 72.0 | 47 | 37.0 | <0.001 | 48 | 38.1 | <0.001 |
| Presence of symptom | 37 | 28.0 | 80 | 63.0 | 78 | 61.9 | ||
| Very bothersome | 5 | 13.5 | 6 | 7.5 | 0.356 | 6 | 7.7 | 0.219 |
| Somewhat bothersome | 11 | 29.7 | 21 | 26.3 | 18 | 23.1 | ||
| A little bothersome | 19 | 51.4 | 50 | 62.5 | 50 | 64.1 | ||
| Not at all bothersome | 2 | 5.4 | 3 | 3.8 | 4 | 5.1 | ||
| Tearing | ||||||||
| Absence of the symptom | 75 | 56.8 | 61 | 48.0 | 0.158 | 64 | 51.2 | 0.367 |
| Presence of the symptom | 57 | 43.2 | 66 | 52.0 | 61 | 48.8 | ||
| Very bothersome | 7 | 12.3 | 4 | 6.1 | 0.129 | 7 | 11.5 | 0.233 |
| Somewhat bothersome | 18 | 31.6 | 18 | 27.3 | 14 | 23.0 | ||
| A little bothersome | 29 | 50.9 | 37 | 56.1 | 33 | 54.1 | ||
| Not at all bothersome | 3 | 5.3 | 7 | 10.6 | 7 | 11.5 | ||
| Dryness | ||||||||
| Absence of the symptom | 80 | 60.6 | 87 | 68.5 | 0.185 | 89 | 71.2 | 0.074 |
| Presence of the symptom | 52 | 39.4 | 40 | 31.5 | 36 | 28.8 | ||
| Very bothersome | 13 | 25.0 | 6 | 15.0 | 0.106 | 4 | 11.1 | 0.057 |
| Somewhat bothersome | 19 | 36.5 | 11 | 27.5 | 9 | 25.0 | ||
| A little bothersome | 15 | 28.8 | 19 | 47.5 | 22 | 61.1 | ||
| Not at all bothersome | 5 | 9.6 | 4 | 10.0 | 1 | 2.8 | ||
| Itching | ||||||||
| Absence of the symptom | 67 | 50.8 | 81 | 64.3 | 0.028 | 81 | 64.8 | 0.023 |
| Presence of the symptom | 65 | 49.2 | 45 | 35.7 | 44 | 35.2 | ||
| Very bothersome | 5 | 7.7 | 1 | 2.2 | 0.220 | 3 | 6.8 | 0.274 |
| Somewhat bothersome | 15 | 23.1 | 8 | 17.8 | 5 | 11.4 | ||
| A little bothersome | 40 | 61.5 | 32 | 71.1 | 33 | 75.0 | ||
| Not at all bothersome | 5 | 7.7 | 4 | 8.9 | 3 | 6.8 | ||
| Soreness, tiredness | ||||||||
| Absence of the symptom | 67 | 50.8 | 81 | 63.8 | 0.035 | 80 | 64.0 | 0.032 |
| Presence of the symptom | 65 | 49.2 | 46 | 36.2 | 45 | 36.0 | ||
| Very bothersome | 6 | 9.2 | 1 | 2.2 | 0.217 | 2 | 4.4 | 0.091 |
| Somewhat bothersome | 24 | 36.9 | 16 | 34.8 | 11 | 24.4 | ||
| A little bothersome | 30 | 46.2 | 24 | 52.2 | 28 | 62.2 | ||
| Not at all bothersome | 5 | 7.7 | 5 | 10.9 | 4 | 8.9 | ||
| Feeling of something in the eye | ||||||||
| Absence of the symptom | 84 | 63.6 | 89 | 70.1 | 0.272 | 83 | 66.4 | 0.643 |
| Presence of the symptom | 48 | 36.4 | 38 | 29.9 | 42 | 33.6 | ||
| Very bothersome | 6 | 12.5 | 4 | 10.5 | 0.472 | 6 | 14.3 | 0.544 |
| Somewhat bothersome | 11 | 22.9 | 8 | 21.1 | 7 | 16.7 | ||
| A little bothersome | 29 | 60.4 | 22 | 57.9 | 25 | 59.5 | ||
| Not at all bothersome | 2 | 4.2 | 4 | 10.5 | 4 | 9.5 | ||
Notes:
*
Glaucoma symptom scale.
a
At baseline, the GSS-SYMP-6 was not completed for the worse eye by 46 of the 178 patients.
b
At week 4, the GSS-SYMP-6 was not completed for the worse eye by 42 of the 169 patients.
c
N = 126 for itching nonvisual symptom; at week 4, the itching nonvisual symptom was not completed for the worse eye by 43 of the 169 patients.
d
At week 8, the GSS-SYMP-6 was not completed for the worse eye by 51 of the 176 patients.
e
N = 126 for burning, smarting and stinging symptoms; at week 8, burning, smarting and stinging symptoms were not completed for the worse eye by 50 of the 176 patients.