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. 2010 Jul 26;5(7):e11754. doi: 10.1371/journal.pone.0011754

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Das et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Chemotaxis of dHL60-CXCR2 cells, in response to gradients of CXCL8 variants, was measured in the microfluidic gradient chambers. Chemotaxis for all variants was measured as a function of both varying steepness and concentration. The data are shown as the mean chemotactic index (C.I.), which is defined as the displacement of cells that move along the Y-axis (direction of gradient) divided by the total migration distance. Statistical analyses were performed with two-way ANOVA with Bonferroni posttests, *p<0.05; ***p<0.001. (B) Movement tracks of ten randomly picked cells in response to different concentration gradients of CXCL8 variants. Gradients of monomer, dimer or WT CXCL8 were delivered into the device by a constant flow (the direction shown by the arrow). The cell movements (Supplemental Videos S1 and S2) were recorded every 20 sec for 30 min and data were analyzed with Metamorph software.