Table 1.
Allele frequencies of SNPs in IL-1 gene cluster in POAG patients and controls
| SNP (Gene) | Allele | Patient Subgroup | Patient (n) | Control (n) | p-value | Adjusted p-Value* | OR (95% CI) |
|---|---|---|---|---|---|---|---|
| -889C/T rs1800587 (IL-1A) |
POAG | 0.71 (448) | 0.204 | - | - | ||
| C | Non-HTG | 0.74 (296) | 0.68 (408) | 0.025 | 0.075 | 1.380(1.041-1.830) | |
| HTG | 0.66 (152) | 0.534 | - | - | |||
| POAG | 0.29 (182) | 0.204 | - | - | |||
| T | Non-HTG | 0.26 (102) | 0.32 (194) | 0.025 | 0.075 | 0.725(0.547-0.961) | |
| HTG | 0.34 (80) | 0.534 | - | - | |||
| -511C/T rs16944 (IL-1B) |
POAG | 0.44 (276) | 0.114 | - | - | ||
| C | Non-HTG | 0.43 (173) | 0.39(237) | 0.197 | - | - | |
| HTG | 0.44 (103) | 0.185 | - | - | |||
| POAG | 0.56 (354) | 0.114 | - | - | |||
| T | Non-HTG | 0.57 (225) | 0.61(365) | 0.197 | - | - | |
| HTG | 0.56 (129) | 0.185 | - | - | |||
| +3953C/T rs1143634 (IL-1B) |
POAG | 0.85 (538) | 0.102 | - | - | ||
| C | Non-HTG | 0.87 (345) | 0.89 (533) | 0.380 | - | - | |
| HTG | 0.83 (193) | 0.039 | 0.117 | 0.641(0.419-0.979) | |||
| POAG | 0.15 (92) | 0.102 | - | ||||
| T | Non-HTG | 0.13 (53) | 0.11(69) | 0.380 | - | - | |
| HTG | 0.17 (39) | 0.039 | 0.117 | 1.561(1.022-2.385) | |||
* P-values were adjusted by Bonferroni method.
The location of the SNP in the genomic region and corresponding dbSNP reference ID is furnished. None of the 3 SNPs was significantly associated with the entire POAG patient cohort or when it is subdivided to two groups: HTG (IOP > 21 mmHg) and non-HTG (IOP < 20 mmHg). The numbers in parenthesis next to 'Allele frequency' represent numbers of chromosomes in the group. The weak association of IL1A (-889C/T) and IL1B (+3953C/T) polymorphisms were nullified after Bonferroni adjustments for multiple tests.