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Changes in fractional anisotropy (FA) and mean diffusivity (MD). Changes in FA and MD precede voxel-based morphometry (VBM) in the peri-ventricular white matter region. Clusters with atrophy by VBM (4A and 4B), reduced FA (4C in red), and increased MD (4 D in blue) in the patient group overlay on the mean skeleton map (in green) (all p < 0.05, corrected at the cluster level). The colored bar indicates the t value in the VBM study.
