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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Hepatology. 2010 Jun;51(6):1912–1921. doi: 10.1002/hep.23587

Figure 2. Silymarin inhibits JFH-1 polymerase at high dose.

Figure 2

HCV NS5B polymerase from isolate JFH-1 (genotype 2a) was incubated with the indicated concentrations of Silymarin or Silibinin, respectively, in presence of [32P]GTP and polyC. Incorporation of radioactivity was quantified by TCA precipitation and liquid scintillation counting. Silymarin and to a lesser degree, silibinin, inhibited JFH-1 polymerase.