Table 3.
Associations between HIF-1α staining pattern, clinicopathological features and expression of CAIX, Glut-1 and p27kip1.
| Perinecrotic HIF-1α | ||||
|---|---|---|---|---|
| Yes (%) | No (%) | P-value | ||
| Stage | I | 30 (56) | 24 (44) | |
| II | 12 (57) | 9 (43) | 0.845 | |
| III | 9 (69) | 4 (31) | ||
| IV | 3 (60) | 2 (40) | ||
| Grade | 1 | 9 (32) | 19 (68) | |
| 2 | 33 (70) | 14 (30) | 0.004 | |
| 3 | 12 (67) | 6 (33) | ||
| Myometrial Invasion | 0 | 0 | 3 (100) | |
| <50% | 29 (58) | 21 (42) | 0.107 | |
| >50% | 25 (63) | 15 (37) | ||
| Necrosis | Yes | 54 (77) | 16 (23) | <0.0001 |
| No | 0 | 23 (100) | ||
| Recurrence/Metastasis | Yes | 14 (79) | 4 (22) | 0.043 |
| No | 37 (51) | 35 (49) | ||
| p27kip1 | Pos | 48 (89) | 38 (97) | 0.125 |
| Neg | 6 (11) | 1 (3) | ||
| p27kip1 | ≤50% | 48 (58) | 35 (42) | 0.896 |
| >50% | 6 (60) | 4 (40) | ||
| p27kip1 expression pattern | Peri/central | 30(91) | 3(9) | <0.0 |
| Other* | 24(40) | 36(60) | 001 | |
| CAIX | Pos | 47 (67) | 24 (33) | 0.004 |
| Neg | 7 (32) | 15 (68) | ||
| Glut-1 | Pos | 48 (63) | 28 (37) | 0.035 |
| Neg | 6 (35) | 11 (65) | ||
| CAIX and Glut-1 | Pos | 42 (68) | 20 (32) | 0.007 |
| Neg | 12 (39) | 19 (61) | ||
HIF-1α = hypoxia-inducible factor 1α; CAIX = carbonic anhydrase IX; Glut-1 = glucose transporter 1, * other staining patterns include diffuse staining or negative for p27kip1.