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(a, b, c, d)- H & E and immunoperoxidase staining (brown) of a BL case showing (a) H & E section with "starry sky pattern," (b) granular membranous and cytoplasmic reactivity in all tumor cells for CD20 antigen, (c) a high proportion of nuclear Ki-67 immunoreactivity (brown) and (d) EBER probe (dark brown) in situ hybridization (ISH) nuclear reactivity in all tumor cells, (all ×400).
