Table 6.
DLBCL (ABC/GCB) subtypes by clinical presentation, viral (HIV/EBV) status, IHC (Ki-67 and BCL-2) and DNA ploidy at MNH (1996-2006)
| Subtypes [No. (%)] |
Sex | Age-group | Clinical Presentation in relation to the diaphragm |
HIV status | Ki-67 reactivity | EBER ISH reactivity | DNA Ploidy | BCL2/Mum1p subtype |
Total [No. (%)] | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M | F | ≤18 | >18 | Supra- | Sub- | Gen | Pos | Neg | Low | High | Pos | Neg | nd | Diploid | Aneuploid | Grp. 1 | Grp. 2 | No.(%) | |
| ABC | 9 (50.0) | 6 (66.7) | 0 | 15 (65.2) | 9 (66.7) | 4 (80.0) | 4 (50.0) | 2 (40.0) | 1 (33.3) | 11 (61.1) | 4 (44.4) | 5 (50.0) | 8 (53.3) | 2 | 6 (66.7) | 9 (50.0) | 7 (36.8) | 8 | 15 (55.6) |
| GCB | 9 (50.0) | 3 (33.3) | 3 | 8 (34.8) | 3 (33.3) | 1 (20.0) | 4 (50.0) | 3 (60.0) | 2 (66.7) | 7 (38.9) | 5 (55.6) | 5 (50.0) | 7 (46.7) | 0 | 3 (33.3) | 9 (50.0) | 12 (63.2) | 0 | 12 (44.4) |
| Total | 18 (66.7) | 9 (33.3) | 3 (11.1) | 23 (88.9) | 12 (44.4) | 5 (18.5) | 8 (29.6) | 5 (62.5) | 3 (37.5) | 18 (66.7) | 9 (33.3) | 10 (37.0) | 15 (55.5) | 2 (7.4) | 9 (33.3) | 18 (66.7) | 19 (70.0) | 8 (30.0) | 27* (100.0) |
*This is the total number of DLBCLs analyzed by FACS for DNA Ploidy
nd = not determined
ABC = activated B-cell like DLBCL, GCB = germinal center B-cell like DLBCL