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. 2010 Mar 11;38(13):4415–4425. doi: 10.1093/nar/gkq129

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Structure comparison of N¹-meA:T lesion with N⁶-meA:T base pair. (A) Side view structure of N¹-meA10:T5′ with neighboring base pairs aligned with N⁶-meA10:T5’. N¹-meA10:T5′ with neighboring base pairs appears in red, and N⁶-meA10:T5′ with neighboring base pairs in green. The figure illustrates a significant dihedral between N¹-meA10 and N⁶-meA10 when two bases are overlaid together. (B) Overlay of N¹-meA10 and adjacent T9 (in red) with N⁶-meA10 and neighbor T9 (in green) as viewed from top. The purine ring of N¹-meA10 is in syn conformation, and the N⁶-meA10 base is in anti-conformation.