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. 2010 Mar 22;38(13):4218–4230. doi: 10.1093/nar/gkq130

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — SI P-values and IP/Totals for a selection of representative mRNAs. (a–f) Combined SI P-values (blue bars, −log₁₀ scale) and IP/Total values (red bars, log₂) across all cell populations. (a) The acetylcholine transporter, Slc18a3 is significantly specific to all four cholinergic cell populations assessed. (b) The interneuronal marker Dlx1 is translated specifically in the Cort and Pnoc bacTRAP lines. (c and d) Ubiquitously expressed genes B-actin(Actb) and ribosomal protein L8(Rpl8) are not specific to any cell type, though translation does vary across cell types. (e and f) The Neurexin autism candidate genes Nrxn1, and Nrxn2, have differential patterns of translation. Nrxn2 is more broadly translated, while Nrxn1 has low to moderate enrichment in cerebellar granule cells and some cortical neuron types.