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The DNMT1-degrading effects of 5-aza-dC are dependent on pre-existing DNA methylation (A) Global DNA methylation in wild-type (J1) ES cells and Dnmt[3a–/–,3b–/–] ES cells. (B) Dnmt1 protein levels of in wild-type and Dnmt[3a–/–,3b–/–] mouse ES cells treated with 1 μM 5-aza-dC for 12 h. The bar graph shows the averaged quantifications with standard deviations (by densitometry) of western blots from three independent experiments.
