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. 2010 Mar 24;38(13):4394–4403. doi: 10.1093/nar/gkq188

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Position of two TINAs in both the TFO and AD strands of the triplex and change in T_m. Parallel triplex with two TINAs in the AD strand and two TINAs in the TFO strand and change in triplex T_m. On both axes TINAs are moved from the centre to the ends of the oligonucleotide. Triplex T_m was determined using 1.0 µM of each strand in NaOAc-buffer at pH 5.0. TINA positions are indicated above the triplex sequence counted from the 5′ to the 3′ position in the target strand, and the numbers reflect the position of the base 5-prime to the TINA bulge insertion. Colour indicates the change in T_m compared with a pure DNA triplex.