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. Author manuscript; available in PMC: 2010 Jul 26.
Published in final edited form as: J Mol Biol. 2006 Apr 27;359(4):913–929. doi: 10.1016/j.jmb.2006.04.004

Figure 5.

Figure 5

Known mutations of Hex A contributing to Tay-Sachs and Sandhoff disease. (a) Stereo view of a ribbon representation of Hex A (wheat), with residues known to disrupt Hex A activity: acute to sub-acute, red; chronic, green; asymptomatic, cyan. (b) A stereo view of the α-subunit of Hex A and residues associated with Tay-Sachs disease. (c) A stereo view of the β-subunit and residues associated with Sandhoff disease.