Table 2.
CYP2A6*23 genotype groups and their mean adjusted 3HC/COT ratio
| Allele | Genotype | n | Mean adjusted 3HC/COT | SD | % of wildtype | p-valuesa |
|---|---|---|---|---|---|---|
| *23 | *1/*1 | 150 | 1.210 | 0.634 | 100 | 0.04 |
| *1/*23 | 4 | 0.756 | 0.540 | 62.4 | ||
| *23/*23 | 1 | 0 | 0 | 0 | ||
| *17 | *1/*1 | 150 | 1.210 | 0.634 | 100 | <0.001 |
| *1/*17 | 19 | 0.672 | 0.468 | 55.5 | ||
| *17/*17 | 3 | 0.109 | 0.095 | 9.1 | ||
| More than one variant | *1/*1 | 150 | 1.210 | 0.634 | 100 | 0.02 |
| *17/*23 | 2 | 0.259 | 0.366 | 21.4 | ||
| *20/*23 | 2 | 0.555 | 0.512 | 45.8 | ||
| *9/*23 | 1 | 1.032 | 0 | 85.2 |
a
The adjusted 3HC/COT ratio was compared between wildtype individuals (CYP2A6*1/*1) to other genotype groups combined using a two-tailed independent t-test.