Figure 2. Development of lethal glomerulonephritis in Tank−/− mice.
(a) The survival of WT (n = 10) and Tank−/− (n = 10) mice was monitored for 1 year. (b,c) Kidney sections from 6-month-old WT and Tank−/− mice were stained with hematoxylin and eosin (H&E) (b) or Periodic acid-Schiff (PAS) (c). (d) Kidney sections from 6-month-old WT and Tank−/− mice were stained with FITC-labeled anti-mouse IgG, IgM, C3 and C1q.