Skip to main content
. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Inorg Biochem. 2010 May 15;104(9):967–977. doi: 10.1016/j.jinorgbio.2010.05.002

Table 3.

Cytotoxic Concentration (CC)50 of Ruthenium compounds measured against Jurkat and SUP-T1 human cell lines analyzed by flow cytometry.

CC50
(µM) a
Cell line 1 2 3 4 5 6 CQDP
SUP-T1 128 88 54 75 70 Non toxicb 130
Jurkat 153 90 81 86 77 129 95
a

CC50 is defined as the concentration of drug required to disrupt the plasma membrane of 50% of cell population, compared to untreated cells, after 20 h of incubation. Cells with compromised plasma membrane were monitored using propidium iodide (PI) and flow cytometry.

b

Even when SUP-T1 cells, a human T-lymphoma cell line, were exposed to 100 µM of [Ru(η6-arene)(en)Cl]PF6 (6), the cytotoxicity measured was similar to that of untreated control cells. All values represent average obtained from triplicates.