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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Neurobiol Dis. 2010 Apr 8;39(3):252–264. doi: 10.1016/j.nbd.2010.03.021

Figure 3. Phrenic nerve hyperstimulation accelerated decline in phrenic nerve compound muscle action potentials (CMAPs) in SOD1G93A rats.

Figure 3

Compared to unstimulated SOD1G93A rats (B), SOD1G93A rats that received high stimulation (C) had reduced phrenic nerve compound muscle action potentials (CMAPs), a functional electrophysiological assay of diaphragm function. CMAPs were recorded at 2 different points during disease progression, and a significant decrease in peak response amplitude was found in stimulated rats at both times (A). No effects of high stimulation on CMAP amplitude was noted in wild-type rats (A).