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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Neurochem. 2010 Apr 29;114(2):430–439. doi: 10.1111/j.1471-4159.2010.06779.x

Figure 1.

Figure 1

Neutral sphingomyelinase activity reversibly increases the population spike (PS) amplitudes. A: A 15 min application of nSMase (0.4 U/ml; gray bar) increases the PS (squares) while having little effect on the fEPSP (circles). The increase in PS amplitudes reverses following washout of nSMase. The data points are the mean and SEM of 5 experiments. Inset: 1 min average representative trace taken at the end of baseline and following 15 min nSMase application. B: Input-output curve generated from a series of stimulation intensities converted to an ES curve. PS and fEPSP were normalized to the maximum baseline PS and fEPSP, respectively. The PS is plotted as a function of fEPSP indicating that nSMase (closed circles) increases the PS elicited by a given fEPSP compared to baseline conditions (open circles). Values are the mean and SEM of 7 experiments.