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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Neurochem. 2010 Apr 29;114(2):430–439. doi: 10.1111/j.1471-4159.2010.06779.x

Figure 3.

Figure 3

nSMase increases action potential firing frequency in CA1 pyramidal neurons. A single depolarizing step ranging from 0.05 to 0.2 nA was given to elicit at least 6–10 action potentials. A: Representative traces showing action potential firing before (baseline) and following a 15 min application of nSMase (nSMase). B: Cumulative result depicting measurement of action potential number prior to (hatch bar) and following the application of nSMase (black bar; nSMase; n=11). C: Frequency-input plot formulated from action potential frequencies determined from 50 pA current steps to 0.25 nA given for 200 msec. nSMase (closed circles) shifted the FI plot to the right when compared to baseline (open circles, n=7). Error bars indicate sem. *Student paired t-test p < 0.05 baseline versus sphingomyelinase treatment.