Figure 3. Dose-dependency of UVB-mediated PAF-R agonist production in human skin.
Human skin explants were sham or UVB-irradiated with various doses of UVB. The epidermis was removed at t = 1 h and lipids extracted and tested for PAF-R agonist activity in FURA-2-AM-loaded KBP cells. Data are the mean ± SE percentage of maximal peak calcium flux induced by 1 µM CPAF and numbers of explants tested from each treatment noted in parentheses. * Denotes statistically significant (p < 0.05) differences in comparison to sham control.