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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Aging Cell. 2010 Apr 29;9(4):545–557. doi: 10.1111/j.1474-9726.2010.00580.x

Fig. 7. Model for the role of eIF4H/DRR-2 in the longevity response to DR.

Fig. 7

Genetic epistasis suggests that eIF4H/drr-2 acts downstream of TOR/let-363, sams-1 and rab-10 but parallel to the S6K pathway, which controls other DR mediators such as PHA-4 and HIF-1, to influence protein translation and longevity. It is not clear, however, whether other translation initiation factors (eIFs), such as eIF4E/ife-2 and eIF4G/ifg-1, act similarly as eIF4H/drr-2 to influence longevity in worms.