Fig. 3.

Pulmonary pathology is decreased in chronic EtOH exposed mice receiving oseltamivir treatment. A.) Schematic of scoring for edema in low magnification lung sections (ovals). Black dots represent lesion distribution with increased dot size representing increased severity (see Materials and Methods for further description of the scores). B.) Mice were infected and treated with oseltamivir as described in Fig. 1A. On day 14 p.i. pulmonary edema was measured. Values represent the clinical score assigned by a blinded Veterinary Pathologist. Data are pooled from 2 independent experiments with 5-9 mice per group. C.) Representative sample of a control water mice receiving no treatment showing minimal levels of pulmonary edema. D.) Representative sample of an untreated EtOH mice with enhanced pulmonary edema. E.) Representative sample of a Water mice receiving oseltamivir treatment showing reduced levels of pulmonary edema. F.) Representative sample of an EtOH mice receiving oseltamivir treatment showing a significant reduction in pulmonary edema compared to untreated EtOH mice. * Represents areas of pulmonary edema. All images shown are at 20x magnification. Data are representative of 2 independent experiments with 5-9 mice per group.