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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Heart Rhythm. 2010 Apr 25;7(8):1141–1148. doi: 10.1016/j.hrthm.2010.04.021

Figure 3. Functional characterization of a genetic locus for the QT interval.

Figure 3

Manhattan plot of SNPs associated with the QT interval with the GINS3 locus encircled (A). A regional plot of the GINS3 locus illustrating the SNPs associated with the QT interval (B). Genes in this region were knocked down in the zebrafish embryo by injecting a morpholino directed against GINS3 (C). Hearts from 48 hour old zebrafish were optically mapped and the action potential duration determined in wild-type and GINS3 morpholino knockout fish (D). Knockdown of GINS3 results in a shortening of the action potential duration. Panels A and B reprinted with permission from Nature Genetics 41, 399–406 (2009).