Table 1.
GWAS Results for Electrocardiographic Intervals.
| ECG traits / Locus | Gene name | References |
|---|---|---|
| PR interval | ||
| MEIS1 | Meis homeobox 1 | 12 |
| SCN5A | Sodium channel, voltage-gated, type V | 12 |
| SCN10A | Sodium channel, voltage-gated, type X | 12 |
| ARHGAP24 | Rho GTPase activating protein 24 | 12 |
| NKX2-5 | NK2 transcription factor related, locus 5 | 12 |
| CAV1/CAV2 | Caveolin 1, 2 | 12 |
| WNT11 | Wingless-type MMTV integration site family, member 11 | 12 |
| SOX5 | Sex determining region Y-box 5 | 12 |
| TBX5/TBX3 | T-box 5, 3 | 12 |
| QT interval | ||
| RNF207 | Ring finger protein 207 | 26,39 |
| NOS1AP | Nitric oxide synthase 1 adaptor protein | 26,39 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 26 |
| SCN5A-SCN10A | Sodium channel, voltage gated, types V and X | 26,39 |
| PLN | Phospholamban | 26,39,40 |
| KCNH2 | HERG / Potassium voltage-gated channel, subfamily H (eag- related), member 2 |
26,39 |
| KCNQ1 | Potassium voltage-gated channel, KQT-like subfamily, member 1 | 26,39 |
| LITAF | Lipopolysaccharide-induced TNF factor | 26,39 |
| NDRG4 | NDRG family member 4 | 26,39 |
| RFFL | Ring finger and FYVE-like domain containing 1 | 39 |
| KCNJ2 | Potassium inwardly-rectifying channel, subfamily J, member 2 | 26 |
| KCNE1 | Potassium voltage-gated channel, Isk-related family, member 1 | 39 |
| RR interval | ||
| MYH6 | Alpha myosin heavy chain | 13 |
| GJA1 | Gap junction protein, alpha 1, 43kDa | 32 |
| CD34 | CD34 molecule | 32 |
| GPR133 | G-protein Coupled Receptor | 32 |
| QRS duration | ||
| TBX5 | T-box 5 | 13 |
| SCN10A | Sodium channel, voltage-gated, type X | 13 |
| CDKN1A | Cyclin Dependent Kinase Inhibitor 1A | 13 |
| DKK1 | Dickkopf-related protein 1 | 13 |