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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Semin Fetal Neonatal Med. 2010 May 10;15(4):230–235. doi: 10.1016/j.siny.2010.03.007

Table 4.

Clinically relevant exposures and situations that modify oxygen sensitivity in animal models

Models Effect of oxygen exposure
Adult animals
 Preconditioning with oxygen ↑ Oxygen tolerance
 Endotoxin exposure ↑ Oxygen tolerance
 Castration ↑ Oxygen tolerance
Fetal or newborn animals ↑ Oxygen sensitivity
 Intrauterine growth restriction ↑ Oxygen sensitivity
 Postnatal nutritional deficit ↑ Oxygen tolerance
 Early weaning ↑ Oxygen tolerance
 Antenatal corticosteroids ↑ Oxygen tolerance
 Endotoxin