Table I.

Genetic glomerular diseases and their associated mutated podocyte genes

Gene	Protein	Associated Disease	Reference
Slit Diaphram
NPHS1	Nephrin	Finnish type NS	(Kestila et al., 1998)
NPHS2	Podocin	Steroid-resistant NS	(Boute et al., 2000)
CD2AP	CD2 associated protein	NS in KO Mice	(Shih et al., 1999)
TRPC6	TRPC6	FSGS	(Winn et al., 2005) (Reiser et al., 2005)
PLCE1	Phospholipase Cε1	Early-onset NS with ESRD	(Hinkes et al., 2006)
Cytoskeleton
ACTN4	α Actin 4	FSGS	(Kaplan et al., 2000)
MYH9	NMMHC-A	FSGS	(Kao et al., 2008)
Nuclear protein
WT1	Wilms’ tumor 1	Denys Drash syndrome	(Jeanpierre et al.,1998)
LMX1B	LIM-homeodomain protein	Nail-patella syndrome	(Rohr et al., 2002)

NS: nephritic syndrome; FSGS: focal segmental glomerular sclerosis; ESRD: end stage renal disease; KO: knock-out.