Table 2.
Summary of mammalian endocytic tethers and their binding proteins
| Thether | Target Organelle | Binding Proteins |
|---|---|---|
| Multiprotein tethers | ||
| Exocyst complex (Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, Exo84) |
Plasma mebrane | Rab11a (Sec15) |
| Arf6 (Sec10) | ||
| TC10 (Exo10) | ||
| Ral (Sec5, Exo84) | ||
| Snapin (Exo70) | ||
| Arp2/3 (Exo70) | ||
| PSD-95 (Sec8) | ||
| Centriolin (Sec15) | ||
| Centralspindlin complex (Cyk4, MKLP1) |
Midbody | Rab11-FIP3 (Cyk4) |
| ECT2 (Cyk4) | ||
| Anillin (Cyk4) | ||
| Cep55 (MKLP1) | ||
| GARP complex (Vps52, Vps53, Vps54) |
TGN | Syntaxin6, Syntaxin16, VAMP4 (Vps53, Vps54) |
| Coiled-coil tethers | ||
| Golgin-97 | TGN | Arl1 |
| Golgin-245 | TGN | Arl1 |
| GCC88 | TGN | ? |
| GCC185 | TGN | Arl1 |
| Rab6 | ||
| Syntaxin16 | ||
| Rab9 | ||
| Rab1,2,15,27B,30,33B,35,36 | ||
| EEA1 | Early/Sorting Endosomes | Rab5 |
| PI3 kinase | ||
| Syntaxin6 | ||
| Rab22a |