Table 1.
Demographic and pathologic information along with RNA data on patient cohort.
| Case | Braak stage (0-VI) |
Age | Sex | PMI (hrs) |
Brain Weight (gms) |
SMT NP Counts |
SMT NFT Counts |
ApoE Alleles |
miR-107 (normalized arbitrary units) |
BACE1 mRNA (normalized arbitrary units) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | I | 75 | F | 3.50 | 1330 | 0 | 0 | 3/3 | 0.59 | 0.71 |
| 2 | I | 100 | F | 2.25 | 1320 | 0 | 0.2 | 2/3 | 0.61 | 0.71 |
| 3 | I | 84 | F | 3.00 | 900 | 0 | 0 | 3/3 | 0.86 | 0.47 |
| 4 | I | 84 | F | 2.50 | 1100 | 0 | 0 | 3/3 | 0.92 | 0.63 |
| 5 | IV | 96 | F | 2.50 | 970 | 0 | 1 | 3/3 | 0.68 | 0.42 |
| 6 | II | 92 | F | 3.00 | 1010 | 0 | 0 | 3/3 | 1.03 | 0.40 |
| 7 | IV | 78 | M | 1.20 | 1130 | 0 | 0 | 3/3 | 0.85 | 0.76 |
| 8 | IV | 91 | M | 2.00 | 1210 | 4.4 | 2.4 | 3/4 | 0.79 | 0.68 |
| 9 | IV | 84 | M | 3.50 | 1350 | 5.6 | 1.2 | 3/4 | 0.65 | 0.64 |
| 10 | III | 86 | F | 3.25 | 1130 | 5.8 | 0 | NA | 0.75 | 0.49 |
| 11 | III | 92 | F | 3.25 | 1220 | 8.2 | 1.2 | 2/3 | 0.71 | 0.72 |
| 12 | 0 | 92 | M | 3.33 | 1220 | 10 | 0 | 3/3 | 0.81 | 0.79 |
| 13 | V | 94 | F | 3.00 | 1070 | 10.8 | 15.8 | 3/3 | 0.82 | 1.20 |
| 14 | V | 94 | M | 2.00 | 1110 | 13.6 | 12.6 | 3/3 | 0.72 | 0.63 |
| 15 | III | 88 | M | 3.00 | 1130 | 16.4 | 0 | 3/3 | 0.69 | 1.27 |
| 16 | VI | 86 | M | 3.25 | 1150 | 16.6 | 41.4 | 3/4 | 0.52 | 0.94 |
| 17 | IV | 77 | M | 2.75 | 1340 | 16.6 | 5.6 | 3/4 | 0.80 | 0.46 |
| 18 | VI | 99 | F | 2.10 | 1150 | 20 | 23.6 | 3/4 | 0.55 | 0.94 |
| 19 | VI | 73 | M | 2.00 | 1130 | 35 | 42.6 | 3/3 | 0.59 | 1.31 |
19 cases were used in the study, arranged from lowest to highest in terms of neuritic plaque density. RNAs are quantified with qPCR--miR-107 is normalized to miR-124 and let-7a. BACE1 mRNA levels were normalized to beta-Actin mRNA. PMI=post-mortem interval. Brain weight is in grams. SMT=superior and mid-temporal cortical gyri. NP = Neuritic plaque. NFT = Neurofibrillary tangle. “Counts” refer to lesion densities (average of five highest 20× fields). N/A=Not available.