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. Author manuscript; available in PMC: 2010 Jul 27.
Published in final edited form as: Nature. 2009 Mar 18;459(7243):108–112. doi: 10.1038/nature07829

Figure 1. Chromatin modifications at promoters are cell type-invariant while those at enhancers are cell type-specific.

Figure 1

We employed ChIP-chip to map histone modifications (H3K4me1, H3K4me3, and H3K27ac) in the ENCODE regions in five cell types (HeLa, GM, K562, ES, dES). (A) We performed k-means clustering on the chromatin modifications found +/− 5 kb from 414 promoters, and observe them to be generally invariant across cell types. (B) As in (A), but clustering on 1423 non-redundant enhancers predicted on the basis of chromatin signatures.