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Initial defects conferred by mutant contractile sarcomeric proteins.
| Mechanical defect |
| Impaired acto-myosin interaction |
| Impaired cardiac myocyte, skeletal myoblasts and myofibril contractile performance |
| Biochemical defects |
| Impaired Ca+2 affinity, force and myofibril sensitivity |
| Bioenergetics |
| Impaired ATPase activity |
| Structural defects |
| Impaired sarcomere assembly |
| Impaired subcellular localization of sarcomeric proteins |
| Altered stoichiometry |
