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. 2010 Jun 18;29(14):2290–2300. doi: 10.1038/emboj.2010.126

Figure 2.

Figure 2

P2X4R-deficient mice show impaired peripheral PGE2 production in response to inflammatory challenge. PGE2 concentrations were measured in paw exudates in saline-injected animals, 2 h post-carrageenan injection (A) or 2 and 4 h after CFA injection (B). In both conditions, PGE2 concentrations were significantly reduced in paw exudates of P2X4R-deficient mice when compared with WT mice. Results were normalized to the mean concentration of PGE2 in WT saline group. N=6 mice per group, *P<0.05, ***P<0.005, Student t-test. (C) Mechanical allodynia was significantly reduced in P2X4R-deficient mice 2 and 4 h post-CFA injection. N=6 mice per group, *P<0.05, one-way ANOVA.