Table 1.
Baseline characteristics in the CHS study, by rapid kidney function decline
| Cystatin C eGFR decline | |||
|---|---|---|---|
| Mean ± SD, median [IQR] or % (N) | |||
| <3 mL/min/year | ≥3 mL/min/year | ||
| (n = 3069) | (n = 1059) | P-value | |
| Age | 72 (5) | 73 (5) | <0.001 |
| Gender (female) | 1906 (62%) | 646 (61%) | 0.524 |
| Race (black) | 391 (13%) | 184 (17%) | 0.001 |
| BMI (kg/m2) | 26.7 (4.5) | 26.8 (4.8) | 0.734 |
| Diabetes | 383 (13%) | 203 (19%) | <0.001 |
| Hypertension | 1670 (55%) | 687 (65%) | <0.001 |
| LDL (mg/dL) | 131 (35) | 130 (36) | 0.402 |
| HDL (mg/dL) | 55 (16) | 55 (16) | 0.493 |
| Triglycerides (mg/dL) | 121 [93, 164] | 118 [91, 163] | 0.232 |
| CRP (mg/L)* | 2.40 [1.24, 4.12] | 2.37 [1.21, 4.39] | 0.900 |
| IL-6 (pg/mL)* | 1.56 [1.08, 2.38] | 1.64 [1.16, 2.39] | 0.095 |
| ICAM-1 (ng/mL)* | 322 (87) | 320 (83) | 0.746 |
| WBC count (cells × 109/L)* | 6.2 (2.1) | 6.3 (1.9) | 0.364 |
| Fibrinogen (mg/dL)* | 320 (64) | 318 (63) | 0.602 |
| Factor VII (%)* | 125 (29) | 124 (30) | 0.275 |
| Factor VIII (%)* | 121 (37) | 121 (37) | 0.777 |
| Albumin (g/dL)* | 4.01 (0.28) | 3.97 (0.29) | <0.001 |
| D-dimer (ng/mL)* | 132 [86, 213] | 144 [96, 231] | 0.019 |
| PAP (nmol/L)* | 5.9 (2.7) | 6.1 (2.4) | 0.360 |
| Cystatin C (mg/L) | 1.04 (0.26) | 0.96 (0.22) | <0.001 |
| Cystatin C-based eGFR (mL/min/ 1.73 m2) | 77 (18) | 85 (21) | <0.001 |
Decline in cystatin C-based eGFR defined as ≥3 mL/min/year; ICAM-1 = intercellular adhesion molecule-1; PAP = plasmin-antiplasmin complex.