Table 2.
Associations of biomarkers (per standard deviation) with decline in cystatin C-based eGFR using logistic regression
| Unadjusted OR | Adjusted* OR | Adjusted** OR | ||
|---|---|---|---|---|
| Biomarker | N | (95% CI) | (95% CI) | (95% CI) |
| C-reactive protein (per SD = 7.74) | 4113 | 1.03 (0.96, 1.10) | 1.02 (0.95, 1.09) | 0.99 (0.92, 1.07) |
| Interleukin-6 (per SD = 1.82) | 3813 | 1.04 (0.97, 1.11) | 1.01 (0.94, 1.08) | 0.99 (0.92, 1.07) |
| ICAM-1 (per SD = 85.59) | 1409 | 0.98 (0.87, 1.10) | 1.00 (0.89, 1.13) | 0.98 (0.86, 1.11) |
| White blood cell count (per SD = 2.02) | 4113 | 1.03 (0.96, 1.10) | 1.03 (0.96, 1.10) | 0.99 (0.93, 1.07) |
| Fibrinogen (per SD = 63.44) | 4107 | 0.98 (0.92, 1.06) | 0.95 (0.89, 1.03) | 0.94 (0.87, 1.01) |
| Factor VII (per SD = 29.25) | 4082 | 0.96 (0.89, 1.03) | 0.99 (0.92, 1.08) | 0.97 (0.89, 1.05) |
| Factor VIII (per SD = 36.75) | 3670 | 1.00 (0.92, 1.08) | 0.97 (0.89, 1.04) | 0.94 (0.86, 1.01) |
| D-Dimer (per SD = 448) | 1628 | 1.00 (0.90, 1.12) | 0.95 (0.84, 1.09) | 0.94 (0.83, 1.07) |
| PAP (per SD = 2.59) | 1659 | 1.04 (0.93, 1.16) | 0.98 (0.87, 1.10) | 0.98 (0.87, 1.10) |
| Albumin (per SD = −0.29) | 4125 | 1.15 (1.06, 1.23)† | 1.11 (1.04, 1.20)† | 1.14 (1.06, 1.23)† |
†P < 0.05.
Decline in cystatin C-based eGFR defined as >3 mL/min/year; ICAM-1 = intercellular adhesion molecule-1; PAP = plasmin-antiplasmin complex
*Adjusted for age, gender and race.
**Adjusted for age, gender, race, hypertension, diabetes, smoking, LDL, HDL, prevalent coronary heart disease and prevalent congestive heart failure.